Effects of Inorganic Iodide on the Intermediary Carbohydrate Metabolism of Surviving Sheep Thyroid Slices.
نویسندگان
چکیده
منابع مشابه
The structural specificity of sulfanilamide-like compounds as inhibitors of the invitro conversion of inorganic iodide to thyroxine and diiodotyrosine by thyroid tissue.
By means of radioactive iodine it was demonstrated in this laboratory that surviving slices of thyroid tissue can incorporate inorganic iodide into diiodotyrosine and thyroxine (1). When 300 mg. of thyroid slices were incubated for 2 hours in a Ringer’s medium containing radioactive inorganic iodide, as much as 60 per cent of the labeled iodine was organically bound, about 50 per cent as diiodo...
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The regulation of thyroid metabolism by iodide involves numerous inhibitory effects. However, in unstimulated dog thyroid slices, a small inconstant stimulatory effect of iodide on H(2)O(2) generation is observed. The only other stimulatory effect reported with iodide is on [1-(14)C]glucose oxidation, i.e., on the pentose phosphate pathway. Because we have recently demonstrated that the pentose...
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In normal rats maintained on an adequate iodine intake, the iodine concentration in the thyroid gland is about 10,000 times as great as that in plasma, a finding that illustrates the remarkable iodine-concentrating capacity of this tissue (1). The fact that almost all of the iodine in the normal gland is organically bound (2, 3) would suggest that this concentrating capacity is dependent upon t...
متن کاملCarbohydrate utilization by beef thyroid tissue.
Preliminary to a study of various pathological thyroid states, it was considered necessary to investigate first the carbohydrate metabolism of the normal gland. Also, it was thought that the information gained regarding the function and energetics of the normal gland might eventually provide an insight into the mechanism of formation of the hormone, thyroxine. Although numerous studies related ...
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Iodide uptake by the thyroid is an active process. Iodine deficiency and pregnancy are known to influence thyroid hormone metabolism. The aim of this study was to clarify the effects of iodine deficiency and pregnancy on iodide uptake by the thyroid. Radioiodide was injected intravenously into nonpregnant and 19-day pregnant rats receiving a normal or marginally iodine-deficient diet. The uptak...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 42 شماره
صفحات -
تاریخ انتشار 1963